pifithrin pft α Search Results


cyclic pifithrin α pft α  (MedChemExpress)
96
MedChemExpress cyclic pifithrin α pft α
Cyclic Pifithrin α Pft α, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pifithrinα hydrobromide  (TargetMol)
96
TargetMol pifithrinα hydrobromide
Pifithrinα Hydrobromide, supplied by TargetMol, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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p53 pathway inhibitor pifithrin α  (Selleck Chemicals)
95
Selleck Chemicals p53 pathway inhibitor pifithrin α
P53 Pathway Inhibitor Pifithrin α, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pft β  (TargetMol)
94
TargetMol pft β
Pft β, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pifithrin-α (pft-α)  (GlpBio Technology Inc)
90
GlpBio Technology Inc pifithrin-α (pft-α)
Pifithrin α (Pft α), supplied by GlpBio Technology Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pifithrin-α (pft-α)/product/GlpBio Technology Inc
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pifithrin-alpha pft-α  (Biomol GmbH)
90
Biomol GmbH pifithrin-alpha pft-α
Pifithrin Alpha Pft α, supplied by Biomol GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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p53 inhibitor pifithrin-α (pft-α  (GlpBio Technology Inc)
90
GlpBio Technology Inc p53 inhibitor pifithrin-α (pft-α
Gentamicin induces cellular ferroptosis through a <t>p53-dependent</t> mechanism. HEI-OC1 cells were treated with 10 μM PFT-α for 24 hours and then with 20 mM gentamicin for 24 hours. Protein expression levels of ( A ) p53 and ( B ) GPX4, and SLC7A11 were evaluated by Western blot. C , Intracellular ROS were detected by DCFH-DA fluorescent probe. D–F, Levels of Fe, MDA, and GSH were determined. * p < 0.05, compared with the gentamicin group. GM indicates gentamicin.
P53 Inhibitor Pifithrin α (Pft α, supplied by GlpBio Technology Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/p53 inhibitor pifithrin-α (pft-α/product/GlpBio Technology Inc
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pifithrin-α pft-α  (Topscience Co Ltd)
90
Topscience Co Ltd pifithrin-α pft-α
Gentamicin induces cellular ferroptosis through a <t>p53-dependent</t> mechanism. HEI-OC1 cells were treated with 10 μM PFT-α for 24 hours and then with 20 mM gentamicin for 24 hours. Protein expression levels of ( A ) p53 and ( B ) GPX4, and SLC7A11 were evaluated by Western blot. C , Intracellular ROS were detected by DCFH-DA fluorescent probe. D–F, Levels of Fe, MDA, and GSH were determined. * p < 0.05, compared with the gentamicin group. GM indicates gentamicin.
Pifithrin α Pft α, supplied by Topscience Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Gentamicin induces cellular ferroptosis through a p53-dependent mechanism. HEI-OC1 cells were treated with 10 μM PFT-α for 24 hours and then with 20 mM gentamicin for 24 hours. Protein expression levels of ( A ) p53 and ( B ) GPX4, and SLC7A11 were evaluated by Western blot. C , Intracellular ROS were detected by DCFH-DA fluorescent probe. D–F, Levels of Fe, MDA, and GSH were determined. * p < 0.05, compared with the gentamicin group. GM indicates gentamicin.

Journal: Otology & Neurotology

Article Title: Regulation of the p53/SLC7A11/GPX4 Pathway by Gentamicin Induces Ferroptosis in HEI-OC1 Cells

doi: 10.1097/MAO.0000000000004271

Figure Lengend Snippet: Gentamicin induces cellular ferroptosis through a p53-dependent mechanism. HEI-OC1 cells were treated with 10 μM PFT-α for 24 hours and then with 20 mM gentamicin for 24 hours. Protein expression levels of ( A ) p53 and ( B ) GPX4, and SLC7A11 were evaluated by Western blot. C , Intracellular ROS were detected by DCFH-DA fluorescent probe. D–F, Levels of Fe, MDA, and GSH were determined. * p < 0.05, compared with the gentamicin group. GM indicates gentamicin.

Article Snippet: To test whether inhibition of p53 attenuated gentamicin-mediated ferroptosis, cells were first treated with or without a p53 inhibitor pifithrin-α (PFT-α; GlpBio, Shanghai, China; 10 μM) for 24 hours, then with 20 mmol/l gentamicin for 24 hours.

Techniques: Expressing, Western Blot